BINDING FOR 5-HT 1A SEROTONINE AND D2 DOPAMINE RECEPTORS.

摘要

THE PRESENT INVENTION IS RELATED TO A NEW SERIES OF COMPOUNDS OF 4-PHENYL PIPERAZINES, 4-PHENYL PIPERIDINES AND 4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINES, OF GENERAL FORMULA (I), WHERE IS ALKYLENE, ALKYLENE, ALKYLEZENE AND CYCLLOALKYLENE C {SUB, 3-7}; R {SUP, 1} IS AN ALKYL GROUP C {SUB, 3-10}, ALKYLENE OR ALKYNYL, CICLOALQU (EN) ILO, CICLOALQU (EN) IL-ALQU (EN / IN)) ILO, TRIFLUOROMETILSULFONILO, R {SUP, 2} -R {SUP, 5} ARE OPTIONAL SUBSTITUTES; R {SUP, 9} AND R {SUP, 10} ARE HYDROGEN, ALKYL, OR UNITED AS A BRIDGE OF ETHYLENE OR PROPYLENE; W ES O O S; V ES O, S, CR {SUP, 6} R {SUP, 7}, O NR {SUP, 8}, WHERE R {SUP, 6}, R {SUP, 7} AND R {SUP, 8}, ARE HYDROGEN OR ALKYL, ALKYNYL, CYCLOALKYL OR CYCLOALKYLALKYL, ARILALKYL OR ARYL OPTIONALLY REPLACED, OR {SUP, 6} YR {SUP, 7} CONSTITUTE A RING RING OF 3-7 MEMBERS; Z IS - (CH {SUB, 2}) {SUB, M} -, BEING M 2 O 3, O Z ES -CH = CH-; X IS N, C O CH. THESE COMPOUNDS SHOW EFFECTS IN THE CENTRAL 5-HT {SUB, 1A} RECEPTORS OF SEROTONIN AND IN THE D {SUB, 2} RECEPTORS OF DOPAMINE. THEREFORE, THE NEW COMPOUNDS ARE USEFUL FOR THE TREATMENT OF CERTAIN PHYSICAL AND NEUROLOGICAL ALTERATIONS, ESPECIALLY PSYCHOSIS.