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cDNA cloning methods for the identification of a CD8+ T- lymphocytes suppressor factor capable of inhibiting HIV-1 replication
cDNA cloning methods for the identification of a CD8+ T- lymphocytes suppressor factor capable of inhibiting HIV-1 replication
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机译:用于鉴定能够抑制HIV-1复制的CD8 + T淋巴细胞抑制因子的cDNA克隆方法
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摘要
The present invention relates to a bioactive molecule, herein referred to as the CD8.sup.+ suppressor molecule, that is produced by the CD8.sup.+ subset of human T-lymphocytes and suppresses type-1 human immunodeficiency virus (HIV-1) replication through inhibition of viral transcription. The invention relates to isolation of clonal CD8.sup.+ cells lines that produce the antiviral activity and the development of an assay system for detection of the antiviral activity. The clonal cell lines and the assay system, described herein, may be utilized to purify, characterize and clone the CD8.sup.+ suppressor molecule. The CD8.sup.+ suppressor molecule may have therapeutic applications for treatment of diseases associated with HIV-1 infection.
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