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Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof

机译：Canadensol紫杉烷类家族，半合成制剂及其治疗用途

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摘要

The present invention relates to a new taxane having the structure as in Formula I, and its analogs as depicted in Formula II and Formula III. The invention includes novel semi-synthetic and isolation methods for the preparation of these novel taxanes. Specifically, the present invention relates to the new taxane Canadensol isolated from plants of the Taxus genus in particular, Taxus canadensis. The present invention further relates to the use of these new taxanes as anticancer agents.

机译：本发明涉及一种新的紫杉烷类，其具有式I的结构，及其类似物如式II和式III所示。本发明包括用于制备这些新型紫杉烷的新型半合成和分离方法。具体地说，本发明涉及从红豆杉属植物，特别是加拿大红豆杉中分离的新的紫杉烷Canadensol。本发明进一步涉及这些新的紫杉烷类作为抗癌剂的用途。 展开▼

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公开/公告号US6410756B1

专利类型

公开/公告日2002-06-25

原文格式PDF

申请/专利权人 INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE;
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申请/专利号US19970957138

发明设计人 YI FENG ZHENG;GAEACUTE;TON CARON;LOLITA ZAMIR;
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申请日1997-10-24

分类号C07D3051/40;

国家 US

入库时间 2022-08-22 00:48:25

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