METHOD OF MANUFACTURING ALBUMIN MICROSPHERES COMPRISING ANTISENSE OLIGONUCLEOTIDES (OLIGOMERS) TO NF-KB

摘要

A method of forming microspheres of a bioactive material, such as an antisense digonucleotide to NF-KB by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages.