A NOVEL SPLICE VARIANT OF MYD88 AND USES THEREOF

摘要

The present invention relates to the field of infection and inflammation and more specifically to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88s), has been identified encoding a protein that inhibits LPS-induced NF-kappaB activation. MyD88s is a target to inhibit the phenomenon of endotoxin-tolerance that occurs in sepsis.