MEANS AND METHOD OF OBTAINING ADHENOVIRUS VECTORS

摘要

The invention relates to methods and means for producing adenoviral vectors on complementing cell lines, wherein the nucleic acid encoding the open reading frame 6 of early region 4 (E4-orf6) is present in the adenoviral vector and the E4-orf6 gene product is compatible with one or more products products of the E1 gene, provided by the complementing cell, so that the adenoviral vector can be efficiently produced by the complementing cell. The international application was published together with a report on the international lawsuit.