NOVEL NUZLEIC ACID CONSTRUCT, VECTOR IN CORPORATING SUCH CONSTRUCT, CELL CONTAINING SUCH CONSTRUCT OR VECTOR, METHOD OF OBTAINING SUCH CONSTRUCT OR VECTOR, APPLICATION OF THEIR OF THEM, CDF-1 PROTEING AND APPLICATION THEREOF, METHOD OF PRODUCING A PHARMACEUTIC AGENT, METHOD OF OBTAINING CDF-1 PROTEING, METHOD OF IDENTIFYING CDF-1 INHIBITORS OR STIMULATORS AS WELL AS PHARMACEUTIC AGENT AS SUCH

摘要

The invention refers to a nucleic acid construct comprising: a) at least one activator sequence b) at least one promotor module comprising a nucleotide sequence which binds a protein of the E2F family and a protein of the CDF-1 family c) at least one structural gene, wherein said promotor module, comprises at least one nucleotide sequence which is selected from the group consisting of ACTTGGCGGGAGATTTGAAT and GCTTGGCGGGAGGTTTGAAT, a process for the preparation of a pharmaceutical containing said nucleic acid construct for use in treatment of a tumor disease and the protein CDF-1 and its use for the search of modulations of its repressor function.