isolated antigen binding polypeptide construct, isolated polynucleotide or set of isolated polynucleotides, vector or set of vectors, isolated cell, pharmaceutical composition, use of the construct, method for treating a subject having a disease or disorder or cancer or vascular disease, method for inhibiting, reducing or blocking a signal within a cell, method for obtaining the construct, method for preparing the construct, computer readable storage medium, computer implemented method, and method for producing a bi-antigen binding polypeptide construct. specific

摘要

isolated antigen-binding polypeptide construct, isolated polynucleotide or set of isolated polynucleotides, vector or set of vectors, isolated cell, pharmaceutical composition, use of the construct, method for treating a subject having a disease or disorder or cancer or vascular disease , method for inhibiting, reducing or blocking a signal within a cell, method for obtaining the construct, method for preparing the construct, computer readable storage medium, computer implemented method and method for producing an antigen binding polypeptide construct "bispecific" present invention provides heterodimer pairs which may comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. at least one of the heterodimers may comprise one or more amino acid modifications in the ch1 and / or cl domains, one or more amino acid modifications in the vh and / or v1 dominoes, or a combination thereof. The modified amino acids may be part of an interface between the light chain and the heavy chain and are usually modified to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are coexpressed in a cell, the heavy chain of the first heterodimer preferably pairs with one of the light chains rather than the other. Similarly, the heavy chain of the second heterodimer usually pairs preferentially with the second rather than the first. 2/2 1/23