Promoter sequences specific for cells of the B lymphoid lineage and pharmaceutical compositions containing the same

摘要

The present invention relates to a nucleic acid sequence comprising or consisting of a S sequence, said S sequence comprising or consisting of:(1) a first sequence corresponding to a fragment of at least 10 nucleotides of the promoter sequence of the human CD19 gene, such as defined in Figure 1, the ends of which being comprised from the nucleotide at position -1500 to the nucleotide at position -1000 of the promoter sequence of the human CD19 gene,(2) a second sequence consisting of the contiguous nucleotides ranging from position -231 to position -1 (SEQ ID NO : 1) of the promoter sequence of the human CD19 gene.