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NON-HUMAN MAMMALI WITH LACKING EXPRESSION OF THE ALPHA6 NICOTINE ACETYLCHOLINE RECEPTOR SUB-UNIT AND USE FOR SCREENING
NON-HUMAN MAMMALI WITH LACKING EXPRESSION OF THE ALPHA6 NICOTINE ACETYLCHOLINE RECEPTOR SUB-UNIT AND USE FOR SCREENING
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机译:α-烟碱乙酰胆碱受体亚单位表达缺乏的非人类哺乳动物及其筛查用途
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摘要
The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. The invention also concerns synaptosome preparations obtained from said animals and cell cultures obtained by mutation of the alpha6 subunit as defined above.
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