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Non-human mammal mutant for expression of the alpha6 subunit of the nicotinic acetylcholine receptor, and use for screening substances that can interact with said receptor
Non-human mammal mutant for expression of the alpha6 subunit of the nicotinic acetylcholine receptor, and use for screening substances that can interact with said receptor
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机译:用于表达烟碱乙酰胆碱受体α6亚基的非人类哺乳动物突变体,并用于筛选可与该受体相互作用的物质
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摘要
The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. ;The invention also concerns synaptosome preparations obtained from said animals and cell cultures obtained by mutation of the alpha6 subunit as defined above.
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