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MUTANT NON-HUMAN MAMMAL FOR EXPRESSING THE ALPHA6 ACETYLCHOLINE NICOTINIC RECEPTOR SUBUNIT AND USE FOR SCREENING SUBSTANCES CAPABLE OF INTERACTING WITH SAID RECEPTOR
MUTANT NON-HUMAN MAMMAL FOR EXPRESSING THE ALPHA6 ACETYLCHOLINE NICOTINIC RECEPTOR SUBUNIT AND USE FOR SCREENING SUBSTANCES CAPABLE OF INTERACTING WITH SAID RECEPTOR
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机译:表达α6乙酰胆碱烟碱受体亚基的突变型非人类哺乳动物以及用于筛选与所述受体相互作用的物质的用途
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摘要
The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. The invention also concerns synaptosome preparations obtained from said animals and cell cultures obtained by mutation of the alpha6 subunit as defined above.
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