GENE THERAPY USING OVINE ADENOVIRAL VECTORS

摘要

A method of gene therapy in a human subject comprising administering to thesubject a viral vector comprising a DNA molecule including a nucleic acidsequence encoding the genome of an ovine adenovirus capable of infecting humancells or functionally equivalent nucleic acid sequence or portion thereof andat least one nucleic acid sequence encoding a gene to be expressed in thecell, such that the viral vector infects at least one cell of the subject andthe infected cell expresses the gene.