PURPOSE: one kind is containing obtaining partially purified extract extract in Ilex or its fraction is provided to and restrained effectively Elastase activity and to ensure wrinkle-proof effect. ;CONSTITUTION: a kind of composition includes to obtain partially purified extract extract or its fraction as effective component in Ilex. The extract is isolated, and uses or mixtures thereof water, organic solvent. It is a kind of to prepare pharmaceutical composition, containing obtained in Ilex partially purified extract extract and fraction it is crease-resistant include: the mixture that partially purified extract Ilex and water, organic solvent or solvent are obtained in extraction step; Itself and step fractionation are extracted, with n-hexane and ethyl acetate. ;The 2011 of copyright KIPO submissions
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