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Method and Apparatus For Automatic Focusing of Substrates in Flourescence Microscopy

机译:在荧光显微镜中自动聚焦基板的方法和设备

摘要

An apparatus for automated examination of biological material (6) includes a microscope (8) with a cross table (9) with the biological material (6) being arranged on the cross table (9) between an object slide (1) or an analysis plate and a cover (4); a light source (15, 16); an evaluation unit; a device for automatic focusing (11); an image recording unit (17) for recording an image of the biological material (6) enlarged via of an object lens (10) of the microscope (8) and for transferring the image to the evaluation unit; and a biochip (2). Labeling (7) is provided on a surface of the biochip (2). Focusing is executable by targeted movement of the cross table (9) based on detection of the labeling (7), and a target interval is determinable by determination of a location and/or a position of the labeling, within which focusing of the biological material takes place.
机译:用于自动检查生物材料( 6 )的设备包括带有交叉表( 9 )和生物材料( 9 )的显微镜( 8 )。 6 )布置在十字工作台( 1 )或分析板与盖板(之间)的十字工作台( 9 )上4 );一个光源( 15、16 );评估单位;自动聚焦设备( 11 );图像记录单元( 17 ),用于记录通过物镜( 10 )的生物材料( 6 )放大的图像。显微镜( 8 ),用于将图像传输到评估单元;和生物芯片( 2 )。在生物芯片( 2 )的表面上提供了标记( 7 )。通过标记的检测( 7 ),可以通过交叉表( 9 )的有针对性的移动来进行聚焦,并且可以通过确定位置和/或确定目标间隔或标记的位置,在该位置发生生物材料的聚焦。

著录项

  • 公开/公告号US2013162804A1

    专利类型

  • 公开/公告日2013-06-27

    原文格式PDF

  • 申请/专利权人 MARKUS MORRIN;

    申请/专利号US201113818551

  • 发明设计人 MARKUS MORRIN;

    申请日2011-08-23

  • 分类号G02B21/00;

  • 国家 US

  • 入库时间 2022-08-21 16:50:46

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