METHOD FOR PREPARING CHIRAL Α-AMINONITRILE USING A CATALYST FOR A STRECKER REACTION

摘要

The present invention relates to a method for preparing chiral α-aminonitrile through a strecker reaction by using a cyanide source under a catalyst having Chemical Formula 1 or Chemical Formula 2 of ethylene glycol derivatives. According to the present invention, chiral α-aminonitriles having various structures and high stereoselectivity can be synthesized. In addition, (R)-type α-aminonitrile, which is a precursor of a synthetically obtainable amino acid, (R)-α-amino acid, can be synthesized to have high optical purity. As the cyanide source, an alkali metal cyanide having good thermal stability, good storing properties, low cost and easy-to-use properties can be used solely, or a combination of the alkali metal cyanide and an alkali metal sulfinate or sulfinic acid can be used. The method according to the present invention is very useful in industrial development, very economical, and simple.