Development of Phase-Transfer-CatalyzedAsymmetric Strecker Reaction Basedon the Molecular Design of Chiral QuaternaryAmmonium Salts

摘要

Asymmetric Strecker reaction of aldimines using aqueouspotassium cyanide (KCN) as a cyanide source has beendevised through the molecular design of chiral phase-transfercatalyst 9 bearing a stereochemically defined tetranaphthylbackbone. Further, highly efficient, enantioselective synthesisof N-protected a-amino nitriles from the corresponding a-amido sulfones under similar biphasic conditions is alsodescribed, featuring its practical advantages.