Sulfur-containing amino acid-producing bacterium and method for producing sulfur-containing amino acid

摘要

A novel technique for improving the production by bacteria of amino acids that contain sulfur has been developed, and thereby a sulfur-containing amino acid-producing bacterium, and a method for producing a compound such as a sulfur-containing amino acid are provided. A sulfur-containing amino acid, a related substance thereof, or a mixture of these can be produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has a sulfur-containing amino acid-producing ability and has been modified so that the activity of the protein encoded by the yeeE gene, for example, the protein of the following (A) or (B), is increased in a medium, and collecting a sulfur-containing amino acid, a related substance thereof, or a mixture of them from the medium: (A) a protein having the amino acid sequence of SEQ ID NO: 14, (B) a protein having the amino acid sequence of SEQ ID NO: 14 but which includes one or several amino acid substitutions, deletions, insertions, or additions, and when the intracellular activity of this protein is increased, the ability of the bacterium to produce a sulfur-containing amino acid is improved.