Preparation of sulfur-containing amino acids and sulfur-containing amino acid-producing bacteria

摘要

To provide a process for the preparation of a compound of sulfur-containing amino acids such as to develop novel techniques for improving the sulfur-containing amino acid-producing ability of the bacteria, with the bacteria and sulfur-containing amino acid-producing bacteria. In and having a sulfur-containing amino acid-producing ability, bacteria belonging to the Enterobacteriaceae family, wherein the bacterium has been modified protein encoded by yeeE gene, for example the activity of the proteins described so as to increase the following (A) or (B) by culturing in a medium, and collecting the mixture thereof, or related materials, or their sulfur-containing amino acid from the medium, to produce these compounds. A protein comprising the amino acid sequence shown in (A) SEQ ID NO: 14. In the amino acid sequence shown in (B) SEQ ID NO: 14, substitution of several amino acids, deletion, insertion, or and consists of an amino acid sequence comprising the addition of one or sulfur-containing amino acids when having an increased activity in a cell protein production ability is improved.