Biomarker for detecting highly pathogenic viral hemorrhagic sepsis virus and diagnostic method

摘要

The present invention relates to an amino acid in which serine (S), the 56th amino acid, is substituted with leucine (L) in the amino acid sequence of viral hemorrhagic sepsis virus (VHSV) consisting of the amino acid sequence represented by SEQ ID NO: 1. An amino acid in which serine (S) as the eighth amino acid is substituted with asparagine (N); an amino acid in which threonine (T) as the 81st amino acid is substituted with alanine (A); valine as the 88th amino acid An amino acid in which (V) is substituted with alanine (A); an amino acid in which glycine (G), which is the 117th amino acid is substituted with aspartic acid (D), and glutamic acid (E), in which the 119th amino acid is substituted; K) 5 to 120 consecutive polypeptides selected from the group consisting of amino acids substituted in (2), the active ingredient Is a technique for detecting a biomarker composition for VHSV detection, comprising using 6 amino acid mutations as a biomarker to detect new VHSV and early diagnosis of fish for VHSV infection It can be used as a biomarker for diagnosing viral hemorrhagic sepsis.