Antiproliferative Compounds, and Pharmaceutical compositions and their uses

摘要

1. Claim 1: a compound characterized by formula (1),O stereoisomers or mixtures of stereoisomers, tautometers, pharmaceutically acceptable salts, solutions, hydrates, cocaine, clarato, isotope scientists or polymers, where R is h, alternative bitumen or alternative cyclopentyl; R1 is an optional cycloarmour chemical, alternative arilo, alternative heteromorphic alternative or alternative heterocyclic chemical alternative; R2 and R3 are halogens respectively; R1 is an alternative,When they were present, they were 1 to 3 Q groups, each of which was a separate asphalt, halogen, halide, hydroxyl, propoxy, alternative cycloquinolones, alternative cyclomethylclathrates, alternative alternatives arilo, - r8308; - or83099;-R⁴SR⁵,-R N (R) (R)R8308;; r8308; (n) (r8310) (r831181) or r8308;; or8308; (c) (J) n (r831181);J is o or s; each r830808 is an independent tar, aluminum or direct link; each r83099 is an independent hydrogen, tar, halogenated tar or hydroxide; r8310y and r8311son, or r8310y and r8311811;Together with the substituted nitrogen atoms, they form an isomerization or isomerization ring composed of 5 to 6 members, which can be replaced by 1 to 2 halogen, tar or halogenated tar.