KDM4B Pharmaceutical composition comprising KDM4B inhibitor for preventing or treating brain disease

摘要

The present invention relates to a pharmaceutical composition for preventing or treating cerebral diseases, which comprises an inhibitor of KDM4B as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cerebral diseases comprising KDM4B inhibitor, H3K27me3) and that inhibition of histone methyltransferase G9a increases expression of ICAM1 by decreasing H3K9me2 and overexpression of G9a inhibits ICAM1 expression, suggesting that methylation of the ICAM1 promoter site regulates the expression of ICAM1 In addition, the histone demethylase KDM4B (Lysine (K) -Specific Demethylase 4B) binds to the ICAM1 promoter region and inhibits the expression of KDM4B, which inhibits the expression of ICAM1, inhibits leukocyte adhesion, By confirming that the expression of Neprilysin protein is increased, the inhibitor of KDM4B of the present invention is useful as a pharmaceutical for the prevention or treatment of brain diseases It may be useful as a hydrous product.