ABCG2 Pharmaceutical composition comprising ABCG2 inhibitor for preventing or treating brain disease

摘要

The present invention relates to a pharmaceutical composition for preventing or treating brain diseases comprising an inhibitor of ABCG2 as an active ingredient. Specifically, it is confirmed that expression of ABCG2 is increased in an ovariectomized mouse, , The expression of ABCG2 was significantly reduced again. When reperfusion was induced after induction of ischemic stroke in mice, the expression of ABCG2 was increased in ovariectomized mice, The expression of ABCG2 was decreased when estrogen was administered. In addition, when estrogen was administered to the endothelial cell line of cerebral vascular endothelium, the expression level and function of ABCG2 were decreased compared with the control group, and the estrogen- Induced ischemia and reperfusion (OGR / R) The inhibition of ABCG2 expression was strongly related to the protective effect of estrogen-induced cerebral vascular endothelial cells, and the inhibition of ABCG2 expression in the cerebral blood vessels By confirming that the survival of the cells is increased and the toxicity of the cells is decreased when inducing ischemia and reperfusion in the endothelial cells, the inhibitor of ABCG2 is useful as a pharmaceutical composition for the prevention or treatment of brain diseases associated with ischemic stroke .