A MULTI-EPITOPE DNA VACCINE FOR HEARTWATER

摘要

Nucleic acids include sequences encoding Ehrlichia ruminantium epitopes which induce a CD4 immune response, and sequences encoding Ehrlichia ruminantium epitopes which induce a CD8 immune response. Multi-epitope DNA vaccines include the nucleic acids and polypeptides are encoded by the nucleic acids. Methods of eliciting an immune response against heartwater disease in a subject make use of the nucleic acids, multi-epitope DNA vaccines and polypeptides.