The present invention relates to a variant polypeptide having geranylgeranyl pyrophosphate synthase activity, wherein the variant polypeptide, when aligned with a geranylgeranyl pyrophosphate synthase comprising the sequence shown in SEQ ID NO: 1, positions 92, 100, Or an amino acid sequence comprising at least one substitution of an amino acid residue corresponding to any amino acid at position 235, said position being defined with reference to SEQ ID NO: 1 and this variant having geranylgeranyl pyrophosphate synthase activity It has one or more altered properties compared to the reference polypeptide it has. The mutant polypeptides of the invention can be used in recombinant hosts for the production of steviol or steviol glycosides. [Selection figure] None
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机译：本发明涉及具有香叶基香叶基香叶基焦磷酸合酶活性的变体多肽，其中，所述变体多肽与香叶基香叶基香叶基焦磷酸合酶的比对时，其包含SEQ ID NO：1、1、92、100所示的序列，或包含至少对应于位置235上任何氨基酸的氨基酸残基的一个取代，所述位置是参考SEQ ID NO：1定义的，并且该变体具有香叶基香叶基焦磷酸合酶活性，与它具有的参考多肽相比，具有一个或多个改变的特性。本发明的突变多肽可用于重组宿主中，以生产甜菊醇或甜菊醇糖苷。 [选择图]无
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