Treatment methods and devices for improving bioavailability of leukotriene receptor antagonists

摘要

Disclosed are administration methods and devices for improving the bioavailability of leukotriene receptor antagonists. The method and device include an oral surface pH oral film dosage form designed to deliver a leukotriene receptor antagonist, such as montelukast, to the stomach in an amorphous precipitate suspended in an aqueous medium. . Also disclosed are devices and methods for treating diseases such as neurodegenerative diseases or conditions associated with leukotriene-induced neuroinflammation. The device is a film unit dosage form with an alkaline surface pH film layer and a safe and effective amount of montelukast. The device is primarily configured to achieve enteral delivery of montelukast. The method involves enterally delivering a safe and effective amount of montelukast (capable of crossing the blood brain barrier) to a human or animal in need of treatment. [Selection diagram] Fig. 5