Design and synthesis of bifunctional peptides:antagonists at CCKA/CCKB receptors and agonists as mu/delta opioid receptors

摘要

Endogenous CCK has been demonstrated to exhibit anti-opioid effects,particularly in the spinal cord.We have hypothesized that the development of novel ligands which possess properties as antagonists at CCK receptors,and as agonista at opioid receptors within the same molecule would present a significant therapeutic advantage in the treatment of pains tates refractory to commonly employed opioids such as morphine.