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一种多肽在治疗骨髓增生异常综合症中的应用

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摘要

本发明公开了一种多肽在治疗骨髓增生异常综合症中的应用，属于生物医药技术领域。本发明筛选得到了能够有效抑制转录因子TWIST1及DNMT3a结合的多肽，其氨基酸序列如SEQ ID NO.1所示，该多肽与其他激酶抑制剂类药物相比，还可增强细胞对地西他滨的敏感性，经动物实验证实，该多肽与地西他滨联用可以有效抑制血液肿瘤的生长，抑制率可达80％，并提高小鼠的生存率，由25％提高至75％。

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公开/公告号CN111135287B

专利类型发明专利
公开/公告日2022-01-11

原文格式PDF
申请/专利权人西北大学;
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申请/专利号CN202010045731.3
发明设计人李想;李鸿姣;关锋;庞星辰;万婷;
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申请日2020-01-16
分类号A61K38/16(20060101);A61K31/706(20060101);A61P7/00(20060101);A61P19/08(20060101);A61P35/02(20060101);
代理机构23211 哈尔滨市阳光惠远知识产权代理有限公司;
代理人仇钰莹
地址 710069 陕西省西安市碑林区太白北路229号
入库时间 2022-08-23 13:00:14

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1. 一种多肽在治疗骨髓增生异常综合症中的应用 [P] . 中国专利： CN111135287B . 2022.01.11
2. 一种多肽、多肽组合物在治疗结肠癌中的应用 [P] . 中国专利： CN109293746A . 2019-02-01
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Pharmaceutical composition, kit of parts, use of factor vii or a factor vii-related polypeptide in combination with a parent-1 or parent-1 related polypeptide, use of a composition, methods for treating bleeding episodes in a subject, to reduce clotting time in one subject, to intensify hemostasis in one subject, to prolong clot lysis time in one subject, and to increase clot resistance in one subject, and kit containing a treatment for bleeding episodes [P] . BR0213952A . 2004-08-31

机译：药物组合物，零件盒，因子VII或因子VII相关多肽与亲本1或亲本1相关多肽的组合使用，组合物的用途，治疗受试者出血发作以减少凝血时间的方法一名受试者中的一种，其用于增强一名受试者中的止血作用，延长一名受试者中的血块溶解时间并提高一名受试者中的血凝块抗性，以及一种包含出血发作治疗的试剂盒
5. Isolated polynucleotide, methods for identifying or amplifying and genotyping all or part of a polynucleotide, for separating a polypeptide, to obtain an immunospecific antibody, for identifying an agent and a compound between one or more compounds to be tested, for analyzing the biological characteristics of a patient, to prevent or treat in an individual a disease and disorder or disease linked to the presence of polynucleotide in the genome, to increase or decrease activity in a polypeptide patient, to statistically determine relevant associations between at least one snp is a disease or disease resistance and for diagnosing or determining a disease prognosis or disease resistance, recombinant vector, host cell, polypeptide, immunospecific antibody, therapeutic agent, and compound [P] . BR0209097A . 2005-04-19

机译：分离的多核苷酸，鉴定或扩增和多核苷酸的全部或部分基因型，分离多肽，获得免疫特异性抗体，鉴定一种或多种待测化合物之间的试剂和化合物，分析其生物学特性的方法患者，以预防或治疗与基因组中多核苷酸的存在有关的疾病和病症或疾病，以增加或降低多肽患者的活性，以统计学方式确定至少一种snp是疾病或抗病性以及用于诊断或确定疾病预后或抗病性的重组载体，宿主细胞，多肽，免疫特异性抗体，治疗剂和化合物