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使产ESBLs的多重耐药菌敏感性恢复的方法

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摘要

本发明公开了一种使产ESBLs的多重耐药菌敏感性恢复的方法，包括如下步骤：(1)从临床选取原始菌株，保藏备用；(2)将所述各原始菌株经增菌、分离制备成菌悬液；(3)转种并经血液增菌肉汤管传代；(4)测定药敏，得出血液增菌肉汤管传代培养得到的细菌的药物敏感性恢复情况。本发明使产ESBLs的多重耐药菌敏感性恢复的方法切实可行，其结果具有准确、可靠的优点。

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公开/公告号CN104611261A

专利类型发明专利
公开/公告日2015-05-13

原文格式PDF
申请/专利权人淮南市妇幼保健院;邢浩莉;
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申请/专利号CN201510046356.3
发明设计人田恒忠;孟祥清;邢浩莉;孙丹;赵淑海;万莉;倪宁;吕红光;任忠;杨洁;李倩;卜小芳;陈玲;尹晓玲;秦国娟;
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申请日2015-01-29
分类号C12N1/20;C12R1/22;C12R1/19;
代理机构北京双收知识产权代理有限公司;
代理人王菊珍
地址 232007 安徽省淮南市田家庵区人民北路67号
入库时间 2023-12-17 04:48:46

法律信息

法律状态公告日

法律状态信息

法律状态
2020-02-11

发明专利申请公布后的驳回 IPC(主分类):C12N1/20 申请公布日:20150513 申请日:20150129

发明专利申请公布后的驳回
2015-06-10

实质审查的生效 IPC(主分类):C12N1/20 申请日:20150129

实质审查的生效
2015-05-13

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1. 使产ESBLs的多重耐药菌敏感性恢复的方法 [P] . 中国专利： CN104611261A . 2015-05-13
2. 一种对产ESBLs大肠杆菌产生耐药性影响的中药筛选方法 [P] . 中国专利： CN103146802A . 2013-06-12
3. method for the rejuvenation of aged cells, method of rejuvenation of cells such as pluripotent embryonic stem (tte) cells, method of somatic cell rejuvenation as pluripotent tte cells through transfection of ct mrna, method of formation of pluripotent diploid tte cells for autologous transplantation by fusing cells from cells with somatic cells of a mammalian individual, method of forming diploid therapeutic cells by fusing non-replicating target cells with somatic cells to induce reprogramming in them, method of executing cell therapy and cosmetic applications that must also use tissue cells or stem cells, method of locally rejuvenating the skin to reduce pigmentation or wrinkles, method of preparing rejuvenation factors from whole cells, method of preparing skin factors reju venescence from nuclei, method of locally rejuvenating an organ, method of rejuvenating somatic cells from mammals and differentiating them into desired cells by an abbreviated process, rejuvenation buffer compos [P] . BRPI0618411A2 . 2011-09-06

机译：衰老细胞的再生方法，多能胚胎干（tte）细胞等细胞的再生方法，通过ct mrna转染将体细胞再生为多能tte细胞的方法，自体移植形成多能二倍体tte细胞的方法将细胞与哺乳动物个体的体细胞融合，通过将非复制靶细胞与体细胞融合以诱导其中的重编程形成二倍体治疗细胞的方法，进行细胞治疗的方法以及还必须使用组织细胞或干细胞的美容应用细胞，使皮肤局部恢复活力以减少色素沉着或皱纹的方法，从全细胞制备恢复因子的方法，从细胞核恢复皮肤因子恢复活力的方法，使器官局部恢复活力的方法，使哺乳动物的体细胞恢复活力并使其分化的方法通过简化的过程进入所需的细胞，复兴缓冲液成分
4. METHOD FOR OBTAINING STEROID DERIVATIVES 1 The invention relates to a new method for producing steroid derivatives having a hydrocarbon residue in the 17a position, saturated or unsaturated, substituted or unsubstituted, or a dicloalkyl radical, and having physiological activity. a prenatal radical, for example, compounds of 3-oxo-13p-ethyl-17a-ethynyl-17, p-oxygone — 4,9,11-triene, consisting in the fact that 3-ethylenedioxy-17-oxo-13 is prepared first 3-ethylgon- 4,9,1 i-triene which is reacted with an ethynylation reagent followed by hydrolysis of the ketal group at the 3 G7a-ethynyl derivative position. However, the ketalization of the 3-oxo group of the corresponding 3,17-dioxosteroid is not selective, with a low yield of the intermediate 3-ketal, which reduces the yield of the target product. In addition, in the known method, a 4,9,11-trienoic steroid with a closed ring A is used as a starting product, which can be obtained with the complete synthesis of a steroid only from an [P] . SU422142A3 . 1974-03-30

机译：获得类固醇衍生物的方法1本发明涉及一种新的制备类固醇衍生物的方法，该类固醇衍生物具有在17a位上的烃基，饱和或不饱和，取代或未取代的，或二氯烷基基团，并具有生理活性。产前自由基，例如3-oxo-13p-ethyl-17a-ethynyl-17，p-oxygone-4,9,11-triene的化合物，其特征在于3-乙烯二氧基-17-oxo-13是首先准备使3-乙基贡-4,9,1 i-三烯与乙炔化试剂反应，然后水解3 G7a-乙炔基衍生物位置的缩酮基。然而，相应的3，17-二氧代甾族化合物的3-氧代基的缩酮化不是选择性的，中间体3-缩酮的产率低，这降低了目标产物的产率。另外，在已知方法中，具有闭环A的4,9,11-三烯类固醇被用作起始产物，其可以仅通过从甲壳素完全合成类固醇来获得。
5. Method for changing the sensitivity characteristic of diluted penetrants and thereafter restoring siad sensitivity [P] . 英国专利： GB1137779A . 1968-12-27

机译：改变稀释渗透剂的敏感性特征然后恢复siad敏感性的方法