METHOD FOR OBTAINING STEROID DERIVATIVES 1 The invention relates to a new method for producing steroid derivatives having a hydrocarbon residue in the 17a position, saturated or unsaturated, substituted or unsubstituted, or a dicloalkyl radical, and having physiological activity. a prenatal radical, for example, compounds of 3-oxo-13p-ethyl-17a-ethynyl-17, p-oxygone — 4,9,11-triene, consisting in the fact that 3-ethylenedioxy-17-oxo-13 is prepared first 3-ethylgon- 4,9,1 i-triene which is reacted with an ethynylation reagent followed by hydrolysis of the ketal group at the 3 G7a-ethynyl derivative position. However, the ketalization of the 3-oxo group of the corresponding 3,17-dioxosteroid is not selective, with a low yield of the intermediate 3-ketal, which reduces the yield of the target product. In addition, in the known method, a 4,9,11-trienoic steroid with a closed ring A is used as a starting product, which can be obtained with the complete synthesis of a steroid only from an

摘要

1355454 Steroids; 4,5-secosteroids ROUSSEL UCLAF 17 March 1972 [19 March 1971] 12579/72 Headings C2C and C2U The invention comprises compounds of Formulae III, IV and V and the preparation therefrom of steroids of Formula I (R is C 1-4 alkyl; and X is optionally substituted C 1-6 aliphatic hydrocarbyl, or C 3-6 cycloalkyl). The various conversions are effected with conventional reagents, the final step (V#I) being a base-induced cyclization.