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Semantic Priming in Anomic Aphasia: a focused investigation using cross-modal methodology

机译:失语症的语义启动:使用跨模态方法的重点研究

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摘要

Background: Semantic priming in individuals with anomic aphasia has never been the primary focus of an investigation. To date, one study investigated the effects of semantic priming in individuals with fluent aphasia (including anomic aphasia), revealing an inconsistency in semantic priming in the anomic group. Parallels from Broca’s aphasia and Wernicke’s aphasia literature may be drawn. However, due to the heterogeneity of anomic aphasia, a focused investigation was necessary. Aims: Semantic priming effects were investigated using a cross-modal pairwise paradigm. It was hypothesised that participants with anomic aphasia would demonstrate priming patterns at a stimulus onset asynchrony (SOA) of 500 ms with slower overall reaction times (RTs) than the control participants. It was further hypothesised that the participants with anomic aphasia might show less inhibition effects than the control participants. Methods & Procedures: Participants with anomic aphasia (n = 11) and healthy control participants (n = 16) completed a lexical decision task where prime–target pairs were present in equal proportions (related, unrelated, and nonwords). A neutral prime condition was also incorporated. Using a cross-modal pairwise paradigm, participants heard a spoken word 500 ms later, a written word appeared on screen (for 4000 ms). Participants were required to make a decision as to whether the written word was real, and RTs were recorded. Outcomes & Results: Linear mixed model analysis was undertaken and revealed no significant two-way interaction effect, indicating both groups showed priming patterns. A main effect of group was evident, showing faster RTs by the control participant group, confirming our hypothesis that people with anomic aphasia primed at an SOA of 500 ms in a similar manner to the control participants, with slower RTs. Conclusions: Semantic priming effects were present in anomic aphasia at relatively short SOAs and may be contributed to by automatic processes. Several parameters are proposed that should be adopted for further investigation into semantic priming in anomic aphasia including electrophysiological measures and manipulation of SOAs and relatedness proportions (RPs) to more precisely measure the effects of controlled versus automatic processes. Such investigation has the potential to inform new assessment and management techniques.
机译:背景:失语症患者的语义启动从未成为研究的重点。迄今为止,一项研究调查了语义启动对流利性失语症(包括失语性失语症)个体的影响,揭示了在语义失常人群中语义启动方面的不一致。可能会得出Broca失语症和Wernicke失语症文献的相似之处。但是,由于失语症的异质性,有必要进行深入研究。目的:使用交叉模式成对范例研究语义启动效应。假设患有失语性失语症的参与者将在500 ms的刺激发作异步(SOA)上表现出启动模式,其总反应时间(RTs)比对照组参与者要慢。进一步假设,患有失语症的参与者可能显示出比对照参与者更少的抑制作用。方法与程序:失语症参与者(n = 11)和健康对照参与者(n = 16)完成了一项词汇决策任务,其中首要目标对以相等比例(相关,无关和非单词)出现。还引入了中性的原始条件。使用交叉模式成对范例,参与者在500毫秒后听到一个口头单词,屏幕上出现一个书面单词(持续4000毫秒)。要求参与者决定书面文字是否真实,并记录RT。结果与结果:进行了线性混合模型分析,未发现明显的双向相互作用效应,表明两组均显示了启动模式。小组的主要作用是显而易见的,对照组的参与者显示出更快的逆转录反应,证实了我们的假设,即失语性失语症患者以500毫秒的SOA引发,与对照组的参与者相似,但逆转录反应较慢。结论:在相对较短的SOA中,失语症存在语义启动效应,并且可能由自动过程引起。提出了一些参数,应采用这些参数来进一步研究失语症的语义启动,包括电生理措施以及SOA和相关性比例(RP)的操纵,以更精确地测量受控过程与自动过程的影响。这种调查有可能为新的评估和管理技术提供参考。

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