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Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients

机译:肾电阻率指数和不同肾脏生物标记物对1型糖尿病患者早期识别肾病的价值的随访

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摘要

AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN.PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Forty diabetic patients did renal Doppler at baseline & after three years.RESULTS: HbA1, waist/hip ratio, albumin/creatinine ratio, lipid profile, NGAL, KIM-1, L-FABP and resistivity index (RI) were significantly increased in follow-up. Twenty patients (41.7%) showed progression to albuminuria. RI showed a significant increase in follow-up study. ROC curve showed that RI and NGAL had the highest sensitivity (100%), followed by L-FABP (90%) and lastly KIM-1 (63.6%) in the prediction of DN.CONCLUSION: High RI, NGAL, KIM-1 & L-FABP can be considered as early markers of diabetic nephropathy in type 1 diabetics and are associated with its progression over time, independent of albuminuria.
机译:目的:评估肾内电阻率指数(RI)和糖尿病性肾病(DN)的不同生物标志物,以及DN的临床体征及其随时间的进展,以早期发现DN。患者与方法:这项纵向研究纳入了48位1型糖尿病患者,在基线和三年后进行了研究。取血样以评估糖基化血红蛋白(HbA1),脂质分布,并取尿样以评估白蛋白/肌酐比值,中性粒细胞明胶酶相关脂钙蛋白(NGAL),肝型脂肪酸结合蛋白(L-FABP )和基线及三年后的肾损伤分子1(Kim-1)。 40例糖尿病患者在基线和3年后进行了肾脏多普勒检查。结果:HbA1,腰围/臀围比率,白蛋白/肌酐比率,脂质分布,NGAL,KIM-1,L-FABP和电阻率指数(RI)均显着升高-向上。 20名患者(41.7%)显示进展为蛋白尿。 RI显示随访研究显着增加。 ROC曲线显示DN的预测中RI和NGAL的敏感性最高(100%),其次是L-FABP(90%),最后是KIM-1(63.6%)。结论:高RI,NGAL,KIM-1 &L-FABP可被认为是1型糖尿病糖尿病肾病的早期标志物,并与其随时间的进展相关,与白蛋白尿无关。

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