首页> 外文OA文献 >Effects of dopaminergic system activation on feeding behavior and growth performance of the sea bass (Dicentrarchus labrax): A self-feeding approach
【2h】

Effects of dopaminergic system activation on feeding behavior and growth performance of the sea bass (Dicentrarchus labrax): A self-feeding approach

机译:多巴胺能系统激活对鲈鱼(Dicentrarchus labrax)的摄食行为和生长性能的影响:一种自摄方法

摘要

Dopamine is synthesized from l-dopa and subsequently processed into norepinephrine and epinephrine. Any excess neurotransmitter can be taken up again by the neurons to be broken down enzymatically into DOPAC. The effect of dopamine on mammalian food intake is controversial. Mice unable to synthesize central dopamine die of starvation. However, studies have also shown that central injection of dopamine inhibits food intake. The effect of dopaminergic system in the fish feeding behavior has been scarcely explored. We report that the inclusion of l-dopa in the diets results in the activation of sea bass central dopaminergic system but also in the significant increase of the hypothalamic serotonin levels. Dietary l-dopa induces a decrease of food intake and feed conversion efficiency that drives a decline of all growth parameters tested. No behavioral effects were observed after l-dopa treatment. l-dopa treatment stimulated central expression of NPY and CRF. It suggests that CRF might mediate l-dopa effects on food intake but also that CRF neurons lie downstream of NPY neurons in the hierarchical forebrain system, thus controlling energy balance. Unexpectedly, dietary administration of haloperidol, a D2-receptor antagonist, cannot block dopamine effects but also induces a decline of the food intake. This decrease seems to be a side effect of haloperidol treatment since fish exhibited a decreased locomotor activity. We conclude that oral l-dopa inhibits sea bass food intake and growth. Mechanism could also involve an increase of hypothalamic serotoninergic tone. © 2013 Elsevier Inc.
机译:多巴胺由左旋多巴合成,然后加工成去甲肾上腺素和肾上腺素。任何过量的神经递质都可以被神经元再次吸收,从而被酶分解为DOPAC。多巴胺对哺乳动物食物摄入的影响是有争议的。无法合成中央多巴胺的小鼠死于饥饿。但是,研究还表明,集中注射多巴胺会抑制食物摄入。很少探讨多巴胺能系统对鱼类摄食行为的影响。我们报告说,在饮食中添加左旋多巴会导致鲈鱼中枢多巴胺能系统的激活,但也会导致下丘脑5-羟色胺水平的显着增加。饮食中左旋多巴会导致食物摄入量和饲料转化效率的下降,从而导致所有测试的生长参数下降。左旋多巴处理后未观察到行为影响。左旋多巴处理刺激了NPY和CRF的中心表达。这表明CRF可能介导左旋多巴对食物摄入的影响,但也表明CRF神经元位于分级前脑系统中NPY神经元的下游,从而控制了能量平衡。出乎意料的是,D2受体拮抗剂氟哌啶醇的饮食管理不能阻断多巴胺的作用,但会引起食物摄入的减少。这种减少似乎是氟哌啶醇治疗的副作用,因为鱼的运动能力降低。我们得出结论,口服左旋多巴会抑制鲈鱼食物的摄入和生长。机制还可能涉及下丘脑5-羟色胺能的升高。 ©2013爱思唯尔公司。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号