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MORPHOLOGICAL TRANSFORMATION OF INTESTINAL GRAFT AFTER CYSTECTOMY WITH ORTHOTOPIC PLASTIC OF THE URINARY BLADDER

机译:膀胱切除术后膀胱切除术后肠道移植物的形态学转化

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摘要

Introduction. The histomorphological state and mechanisms of transformation of the intestinal epithelium of the orthotopic urinary bladder are unexplored.Purpose of research. The study the morphological adaptive and compensatory changes in the intestinal graft wall (IGW) and their relationship with homeostasis at various stages after surgical treatment. Materials and methods. The morphological state of the intestinal graft wall (IGW) was studied in 42 patient’s cystectomy undergoing with the formation of an orthotopic intestinal bladder (15-ileum, 27-sigmoid) at terms from 1 to 6.5 months and 1 year or more after the treatment.Results. Morphological changes occurring in the IGW wall begin with the moment of urine entering the lumen, which occurs in combination with changes in the stereotyped dynamics of the organ. Expressed changes are observed in all parts of the wall of the small and large intestine. There is regeneration and restructuring of the epithelium, expressed in atrophy and a decrease in the number of suction cylindrical cells and an increase in the number of mucus-forming goblet elements, terminating by 12 months and more after the operation. This combined with a decrease in the number and size of villi and crypts, reduction of the lymphatic channel and sclerosis of the blood vessels and stroma blocks suction. An increase in the number of mucus-forming goblet cells provides a barrier that protects the IGW mucosa from the effects of urine.Conclusion. Morphological changes occurring in the IGW wall under the influence of urine contribute to the preservation of homeostasis and are identical in the thick and thin-intestinal variant of plastic of the bladder.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest
机译:介绍。该组织形态学状态和原位膀胱的肠上皮细胞转化的机制unexplored.Purpose的研究。该研究在肠移植物壁(IGW)形态学自适应和代偿性改变和手术治疗后,在各阶段对体内平衡他们的关系。材料和方法。肠移植物壁的(IGW)形态学状态在42患者的膀胱切除术经受了研究用从1至6.5个月治疗后,在条件形成一个原位肠膀胱(15-回肠,27乙状结肠)和1年或更长时间。结果。形态学变化在IGW壁发生开始的尿进入该腔的时刻,发生在结合在该器官的刻板动力学变化。表达变化在小肠和大肠的壁的所有部分观察到。有再生和上皮的重组,萎缩和在抽吸圆筒型电池的数目和增加的粘液形成杯状元件的数量的降低表达,12个月,更操作之后终止。此结合绒毛和隐窝,减少血管和间质块吸力的淋巴通道和硬化的数目的减少和尺寸。在形成粘液杯状细胞的数目的增加提供了保护从urine.Conclusion的效果IGW粘膜屏障。形态学变化在IGW壁产生的影响尿有助于动态平衡的保存和在的bladder.Disclosure塑料的厚和薄肠变体相同下:本研究没有赞助。该作者声明没有利益冲突

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