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Non-viable human embryos as a source of viable cells for embryonic stem cell derivation

机译:非活性人胚作为胚胎干细胞衍生物的活细胞来源

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摘要

Human embryonic stem cells (hESC) hold great promise for use in regenerative medicine. However, the extraordinary potential of hESC as therapeutic tools is tempered by ethical, moral and political issues surrounding their derivation from human embryos. It has previously been proposed that ethical criteria applied to essential organ donation could be employed for derivation of hESC from irreversibly arrested, and thus organismically dead, human embryos produced during routine IVF procedures. Here, it is shown that arrested embryos do not resume normal development during extended culture, yet most of them contain a substantial number of living cells on embryonic day 6 (72% have >1 viable cell, 47% have >5 viable cells), suggesting that this class of non-viable embryos could be a rich source of viable cells for derivation of hESC lines.
机译:人胚胎干细胞(HESC)对再生医学持有巨大的希望。然而,作为治疗工具的HESC的非凡潜力是由围绕人胚胎衍生的道德,道德和政治问题的锻炼。先前已经提出,应用于基本器官捐赠的道德标准可以用于从不可逆转地被捕的HESC衍生,因此在常规IVF程序期间产生的有机死亡,人胚。在这里,显示被捕的胚胎在扩展培养期间不会恢复正常发育,但大多数胚胎含有大量的活细胞在胚胎第6天(72%> 1活细胞,47%有> 5个活细胞),表明这类不可行的胚胎可能是具有衍生HESC线的丰富的活细胞来源。

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