Effects of crosslinking density on viability and maintenance of human embryonic stem cell-derived cardiomyocytes in elastin-like hydrogels

摘要

Understanding cell-microenvironment interactions is important for the development of cardiac scaffolds. Here, we have shown that human ESC-CMs remain viable in elastin-like hydrogels, where the phenotype and function of these cells is maintained for up to 2 weeks. Additionally, increased crosslinking density has been shown to delay the onset but not the rate of spontaneous contraction within these hydrogels.