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Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

机译：具有独特铰链绑定模式的新型CHK1激酶抑制剂的新型系列

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Xiaohua Huang; Cliff C. Cheng; Thierry O. Fischmann; José S. Duca; Xianshu Yang; Matthew Richards; Gerald W. Shipps;
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年度 2012
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1. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site [J] . Chen Hongming, Tucker Julie, Wang Xiaotao, Acta crystallographica. Section F, Structural biology communications . 2016,第5期

机译：在ERK5中发现新型变构抑制剂结合位点：与规范激酶铰链ATP结合位点的比较
2. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery [J] . Wang Yanli, Sun Yuze, Cao Ran, Journal of Medicinal Chemistry . 2017,第20期

机译：用于激酶抑制剂发现的新型铰链绑定支架的硅鉴定
3. Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes. [J] . Jelic D, Mildner B, Kostrun S, Journal of Medicinal Chemistry . 2007,第6期

机译：人Fyn激酶结构的同源性建模：迷迭香酸作为一种新的Fyn激酶抑制剂的发现以及其可能的结合方式的计算机研究。
4. LC-MS Based Approach to Characterize Non-Specific Binding Inhibitors to Mycobacterium tuberculosis Shikimate Kinase (MtSK) [C] . Mansour S. Alturki, Madison A. Jarrard, Rene F. Ngouli, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：基于LC-MS的方法表征非特异性结合抑制剂对结核分枝杆菌血管分枝杆菌Shikimate激酶（MTSK）
5. Characterization of a Human Immunodeficiency Virus (HIV) Type I Integrase Inhibitor-Binding Pocket and Discovery of Novel Inhibitors Potent against Drug-Resistant Variants of HIV [D] . Crosby, David Charles 2010

机译：人类免疫缺陷病毒（HIV）I型整合酶抑制剂结合口袋的表征和新型抗HIV药物耐药变体的抑制剂的发现
6. Discovery of a Novel Seriesof CHK1 Kinase Inhibitorswith a Distinctive Hinge Binding Mode [O] . Xiaohua Huang, *, †, 2012

机译：小说系列的发现CHK1激酶抑制剂独特的铰链装订模式
7. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site [O] . Hongming Chen, Julie Tucker, Xiaotao Wang, 2016

机译：ERK5中新型变构抑制剂结合位点的发现：与规范激酶铰链ATP结合位点的比较
8. Solution structure analysis of the conformational changes that occur upon the binding of the protein kinase inhibitor peptide to the catalytic subunit of the cAMP dependent protein kinase [R] . Mitchell, R. D. , Walsh, D. A. , Olah, G. A. , 1994

机译：蛋白激酶抑制剂肽与camp依赖性蛋白激酶催化亚基结合后发生的构象变化的溶液结构分析

Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

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