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Use of atr kinases and chk1 kinase inhibitors-containing medicaments for treating cancer
Use of atr kinases and chk1 kinase inhibitors-containing medicaments for treating cancer
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机译:含atr激酶和含chk1激酶抑制剂的药物在治疗癌症中的用途
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摘要
The present invention relates to methods of treating cancer in a patient by administering a compound useful as an inhibitor of ATR protein kinase in combination with a compound useful as an inhibitor of Chk1 protein kinase. The aforementioned combination displays a surprising synergistic effect in treating cancer despite the targeted protein kinases being within the same biological pathway. Moreover, the present invention also relates to methods of treating cancer by administering a compound useful as an inhibitor of ATR protein kinase; administering a compound useful as an inhibitor of Chk1 protein kinase; as well as administering a DNA damaging agent to a patient. The compounds utilized in this invention are represented by formula I and formula II: wherein the variables are as defined herein.
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