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Cognitive processing characteristics in obsessive-compulsive disorder subtypes

机译:强迫症亚型的认知加工特征

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摘要

Obsessive Compulsive Disorder (OCD) is classified as an anxiety disorder characterized by distressing persistent unwanted ideas or impulses (obsessions) and urges and/or compulsion to do something to relieve the associated anxiety caused by the obsession. The thematic content of the obsessions are highly variable, ranging from symmetry, contamination to aggressive concerns. Compulsions tend to be linked to the obsessions, but can also be idiosyncratic to the intrusive thought. According to the cognitive model, Obsessive-compulsive disorder (OCD) is maintained by various belief factors such as an inflated sense of responsibility, overestimation of threat and the over-control of thoughts. Despite much support for this hypothesis, there is a lack of specificity. This series of studies sought to determine the relationship between a number of cognitive beliefs and appraisal processes and obsessive-compulsive symptoms. This thesis presents the results of three studies. The first study was designed to investigate the hypothesis that certain beliefs are more prevalent in OCD, compared with other anxiety disorders. The second study expands on earlier findings by examining whether the six metacognitive beliefs proposed by the Obsessive Compulsive Cognitions Working Group, (OCCWG; 1997, 2001, & 2003) correlate with specific symptom-based OCD subtypes. The final study addresses some of the methodological weaknesses inherent in retrospective self-report measures by replicating the study using experimental techniques. Most importantly, this research was conducted from within the theoretical framework of Rachman (1993) and Salkovskis (1989) models which emphasise the misinterpretation of significance of the intrusive thoughts. The first study explored the relationship between thought-action fusion (TAF) and inflated responsibility beliefs across individuals diagnosed with obsessive compulsive disorder (OCD), an anxiety disorder other than OCD (anxious controls; AC), and a non-anxious control group (NAC). It was hypothesized that the OCD group would evidence significantly higher inflated responsibility and TAF scores, compared to the AC and NAC groups. In this study, non-clinical and clinical participants were recruited for research. The non-clinical group was comprised of undergraduate students (n = 22: mean age = 26.8; SD = 9.2). The clinical groups included 20 participants with OCD as their primary diagnosis (mean age = 32.1; SD = 11.9) and 21 individuals diagnosed with another anxiety disorder (mean age = 32.2; SD = 10.9). To measure inflated responsibility beliefs and thought action fusion, self-report questionnaires were administered to the participants. The results of this study demonstrated that inflated responsibility beliefs, while present in other anxiety disorders, were significantly higher in participants with OCD, even after controlling for depressed mood and TAF levels. No group differences emerged between the OCD and anxious groups on measures of TAF. Thus, it can be tentatively concluded that inflated responsibility beliefs may have a more robust relationship with OCD than TAF beliefs, which appear to act as a general vulnerability factor occurring along a continuum of anxiety disorders. The second study examined the associations between the six OCD-related beliefs: control of thoughts, importance of thoughts, responsibility, intolerance of uncertainty, overestimation of threat and perfectionism and five empirically derived OCD subgroups. Clinical participants with a primary diagnosis with OCD (n = 67: mean age = 38.0; SD = 11.7) were recruited over a period of two years from the Anxiety Disorders Unit. Participant responses were cluster analysed to form five stable groups: aggressive obsessions-checking compulsions (n = 22: mean age = 26.8; SD = 9.2); contamination obsessions-cleaning compulsions (n = 22: mean age = 26.8; SD = 9.2); symmetry concerns-ordering/arranging compulsions (n = 22: mean age = 26.8; SD = 9.2); hoarding obsessions-hoarding compulsions (n = 22: mean age = 26.8; SD = 9.2); and miscellaneous obsessions -miscellaneous compulsions (n = 22: mean age = 26.8; SD = 9.2). The second found that intolerance of uncertainty was significantly related to the contamination subgroup. While responsibility and threat estimation beliefs were higher in the aggressive-checking subgroup, these differences did not reach statistical significance. No other significant results were found, however, there was a non-significant trend for perfectionism beliefs to be higher in symmetry-ordering and hoarding subgroup. Following the results of this study, questions remained about whether the lack of significant findings reflected the generality of these beliefs or were due to methodological differences. This led to the development of the final study presented in this thesis. The purpose of the final study was to investigate whether the second study was limited by the method of assessment (e.g. self-report questionnaires). This study was unique, as it was the first of its kind to experimentally manipulate all six beliefs in empirically derived OCD subtypes. Twenty participants (mean age = 45.0; SD = 11.0) were chosen from the second study to form the following priori groups: contamination (n = 4: mean age = 44.5; SD = 9.5); aggressive (n = 6: mean age = 46.5; SD = 7.2); hoarding (n = 4: mean age = 47.2; SD = 6.9); and symmetry (n = 6: mean age = 41.8; SD = 17.4). Six behavioural experiments designed to reflect one of the six OCCWG beliefs were specifically developed and administered to the groups. Baseline scores were obtained using self-report questionnaires. The study found strong support for the use of experimental paradigms over self-report measures, as several significant interactions between cognitive beliefs and OCD symptom-based subtypes were found. Specifically, the hoarding subgroup evidenced significantly higher overall thought action fusion scores compared to those in the contamination group. The symmetry subgroup exhibited significantly higher anxiety than the aggressive group during the perfectionism task and demonstrated significantly higher scores on several items measuring perfectionism compared to the contamination group. Finally, over-estimation of threat beliefs was significantly higher in the contamination thoughts. No statistically significant group differences were found for controllability of thoughts, responsibility and intolerance of uncertainty. In conclusion, these studies collectively showed that in some cases of OCD certain beliefs appear highly applicable, whereas in others they are not. This finding may explain why some OCD patients have poor treatment outcomes as the beliefs and appraisals were highly variable across groups. These findings are of both theoretical and clinical significance because they add to the growing understanding that OCD may consist of distinct clusters of symptoms with different underlying motivations and beliefs. This finding is of clinical significance because treatment guidelines for OCD can become more specific, factoring into the therapy situation these underlying beliefs and appraisal processes. Lastly, the findings regarding inflated responsibility deserve special mention, given the significance of this construct in contemporary cognitive models. The results of the present studies were mixed with regard to responsibility as only the first study found a significant result. It appears that, like the other belief domains proposed by the OCCWG, responsibility may not be specific to all types of OCD and current cognitive models may benefit was shifting the emphasis to other belief domains.
机译:强迫症(OCD)被归类为焦虑症,其特征是困扰持续不断的不想要的想法或冲动(强迫),并敦促和/或强迫去做一些事情以减轻由强迫症引起的相关焦虑。强迫症的主题内容变化很大,范围从对称,污染到侵略性问题。强迫往往与强迫症有关,但也可能与侵入性思想特质有关。根据认知模型,强迫症由各种信念因素维持,例如责任感过高,威胁的高估和思想的过度控制。尽管对此假设有很多支持,但仍缺乏特异性。这一系列的研究试图确定许多认知信念与评估过程和强迫症之间的关系。本文提出了三项研究的结果。第一项研究旨在调查以下假设:与其他焦虑症相比,某些信念在强迫症中更为普遍。第二项研究通过检查强迫症认知工作组(OCCWG; 1997、2001和2003)提出的六种元认知信念是否与特定的基于症状的强迫症亚型相关联,从而扩展了早期的发现。最终研究通过使用实验技术来复制研究,从而解决了回顾性自我报告方法固有的方法学缺陷。最重要的是,这项研究是在Rachman(1993)和Salkovskis(1989)模型的理论框架内进行的,这些模型强调对侵入性思想的重要性的误解。第一项研究探讨了被认为患有强迫症(OCD),非强迫症(ACD)以外的焦虑症和非焦虑对照组(TAD)与过分负责的信念之间的关系。 NAC)。有假设认为,与AC和NAC组相比,OCD组的虚假责任感和TAF分数明显更高。在这项研究中,招募了非临床和临床参与者进行研究。非临床组由本科生组成(n = 22:平均年龄= 26.8; SD = 9.2)。临床组包括20位以OCD为主要诊断的参与者(平均年龄= 32.1; SD = 11.9)和21位被诊断患有另一种焦虑症的个体(平均年龄= 32.2; SD = 10.9)。为了衡量夸大的责任信念和思想行动融合,对参与者进行了自我报告调查问卷。这项研究的结果表明,强迫症的信念虽然存在于其他焦虑症中,但即使在控制情绪低落和TAF水平后,也明显高于强迫症参与者。在TAF措施方面,强迫症和焦虑组之间没有出现群体差异。因此,可以初步得出结论,与TAF信念相比,膨胀的责任信念与强迫症的联系可能更牢固,而TAF信念似乎是沿着连续性焦虑症发生的一般易感性因素。第二项研究考察了与强迫症相关的六种信念之间的联系:思想控制,思想的重要性,责任感,不确定性的不容忍,对威胁和完美主义的过高估计以及从经验得出的五个强迫症亚组。在两年的时间里,从焦虑症部门招募了具有OCD(n = 67:平均年龄= 38.0; SD = 11.7)的主要诊断的临床参与者。参与者的反应被聚类分析以形成五个稳定的组:积极的强迫症-检查强迫(n = 22:平均年龄= 26.8; SD = 9.2);强迫清洁污染(n = 22:平均年龄= 26.8; SD = 9.2);对称性涉及顺序/安排强迫(n = 22:平均年龄= 26.8; SD = 9.2);积痴迷-ho积强迫(n = 22:平均年龄= 26.8; SD = 9.2);和其他强迫症-其他强迫症(n = 22:平均年龄= 26.8; SD = 9.2)。第二个发现不确定性的不容忍度与污染亚组显着相关。尽管积极检查亚组的责任心和威胁估计信念较高,但这些差异并未达到统计学意义。没有发现其他显着结果,但是,完美主义信念在对称顺序和ard积亚组中有更高的趋势。根据这项研究的结果,有关是否存在重大发现是否反映了这些信念的普遍性还是由于方法上的差异,仍然存在疑问。这导致了本文提出的最终研究的发展。最终研究的目的是调查第二项研究是否受到评估方法(例如自我报告调查表)的限制。这项研究是独一无二的,因为它是该类研究中第一个通过实验操作经验性OCD亚型的所有六种信念的研究。从第二项研究中选出20名参与者(平均年龄= 45.0; SD = 11.0)以形成以下先验组:污染(n = 4:平均年龄= 44.5; SD = 9.5);好斗的(n = 6:平均年龄= 46.5; SD = 7.2);积(n = 4:平均年龄= 47.2; SD = 6.9);对称(n = 6:平均年龄= 41.8; SD = 17.4)。专门制定了六个旨在反映六种OCCWG信念之一的行为实验,并对其进行了管理。使用自我报告调查表获得基线分数。这项研究发现,对于认知模式和强迫症基于症状的亚型之间的几种重要相互作用,他们强烈支持使用实验范式来进行自我报告。具体而言,the积亚组的总体思想行动融合得分明显高于污染组。在完美主义任务中,对称亚组比积极组表现出明显更高的焦虑感,与污染组相比,在测量完美主义的几项上表现出明显更高的分数。最后,在污染思想中,对威胁信念的高估明显更高。在思想的可控性,责任感和不确定性的不容忍度方面,没有发现具有统计学意义的群体差异。总之,这些研究共同表明,在强迫症的某些情况下,某些信念似乎非常适用,而在另一些情况下却没有。这一发现可以解释为什么某些强迫症患者的治疗结果较差,因为信念和评估在各组之间差异很大。这些发现具有理论和临床意义,因为它们加深了人们对OCD可能由具有不同潜在动机和信念的独特症状簇组成的认识。这一发现具有临床意义,因为OCD的治疗指南可以变得更加具体,并将这些潜在的信念和评估过程纳入治疗状况。最后,鉴于这种构造在当代认知模型中的重要意义,有关责任过高的发现值得特别提及。本研究的结果在责任方面参差不齐,因为只有第一项研究发现了显着结果。似乎像OCCWG提出的其他信念领域一样,责任可能并非特定于所有类型的OCD,并且当前的认知模型可能正在受益,正在将重点转移到其他信念领域。

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