NTP Technical Report on the Toxicology and Carcinogenesis Studies of Tetralin (CAS NO. 119-64-2) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Tetralin in Male NBR Rats (Inhalation Studies)

摘要

Tetralin is used as an industrial solvent primarily fornaphthalene, fats, resins, oils, and waxes; as a solventand stabilizer for shoe polishes and floor waxes; as a solvent for pesticides, rubber, asphalt, and aromatic hydrocarbons (e.g., anthracene); as a dye solvent carrier in the textile industry; as a substitute for turpentine in lacquers, paints, and varnishes; in paint thinners and as a paint remover; in alkali-resistant lacquers for cleaning printing ink from rollers and type; as a constituent of motor fuels and lubricants; for the removal of naphthalene in gas distribution systems; and as an insecticide for clothes moths. Tetralin was nominated by the National Cancer Institute for carcinogenicity and disposition studies because of its structure, high production volume, and high potential for worker and consumer exposure. Maleand female F344/N rats and B6C3F1 mice were exposed to tetralin (at least 97% pure) by inhalation for 2 weeks, 3 months, or 2 years; male NCI Black Reiter (NBR) rats were exposed to tetralin by inhalation for 2 weeks. Male NBR rats do not produce alpha 2u-globulin; the NBR rats were included to study the relationship of alpha 2u-globulinand renal lesion induction. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichiacoli, and mouse peripheral blood erythrocytes.