The Immune Status of Patients with Severe Periodontal Disease

摘要

This is a final report of results of a two year contract undertaken by the School of Dental Medicine of the University of Pennsylvania for the National Institute of Dental Research. The objective was to assess the immunologic status of patients with severe periodontal disease and to compare the findings with those of control patients who were essentially free of this disease. As part of this effort the University of Pennsylvania prepared antigens from selected oral organisms designated by the N.I.D.R. after consultation among the three contracting institutions engaged in this effort. The data consist of 3 categories of findings: (1) Baseline data which are the characteristics, oral and systemic which were present at the beginning of the survey in both populations of patients. (2) Indicators of cell mediated immunity as measured by blastogenesis and LIF in both groups of patients using the designated antigens from oral organisms. (3) Humoral indicators of immunity in the form of immunoglobulin levels and Farr tests for specific antibody binding of the antigens in both serum and saliva.