Testing of Respiratory, Enteric and Bacterial Vaccines and Epidemiology of Infectious Diseases in Adolescents, Adults and Children. Annual Report February-November 1987

摘要

During the reporting period, the contractors continued to perform surveillance for acute respiratory and gastrointestinal virus infections. A major portion of the effort was directed at performance of studies of live attenuated influenza A virus vaccines. These studies included determination of human infectious dose(sub 50) for both cold adapted and avian reassortant vaccines, and studies of single gene influenza A virus reassortants. Comparisons of protection afforded by live and inactivated vaccines against experimental challenge in subjects with varying levels of pre-existing serum antibodies were also carried out. Studies to examine the safety and immunogenicity of live virus vaccines in high-risk, elderly subjects were also conducted. In the fall of 1987, the authors began a large scale, placebo-controlled field trial of two live attenuated rotavirus vaccines, RRV-1 and DxRRV-1 in 2-4 month old infants. Finally, evaluation of AIDS vaccines has been added to the work scope of the contract during the above reporting period, and preparation for phase 1 studies of candidate subunit AIDS vaccines and a vaccinia vector AIDS vaccine were also begun.