Modified immunoglobulin, molecule, isolated nucleic acid, cell containing the same, recombinant non-human animal, pharmaceutical composition, vaccine composition, processes for identifying or measuring or detecting a cancer antigen, an antigen from an infectious disease agent, a ligand, and a receptor in a sample. to be tested, kits for detecting a cancer antigen, an infectious disease agent antigen, a cell receptor for an infectious disease agent, a ligand, and a cancer antigen, diagnostic processes or testing for the presence of or a predisposition for the development of a cancer by the increased presence of a cancer antigen, and for the presence of an infectious disease, treatment or prevention of a cancer by the presence of a cancer antigen, of an infectious disease typified by the presence of an antigen infectious disease agent, and a disease caused by an infectious disease agent that binds to a cell receptor, processes for modulating activity of a first member of a binding pair,

摘要

"MODIFIED IMMUNOGLOBULIN, MOLECULE, ISOLATED ACIDONUCLEIC, CELL CONTAINING THE SAME, RECOMBINANT ANIMALHUMAN, PHARMACEUTICAL COMPOSITION, VACCINE COMPOSITION, PROCESSING TO IDENTIFY AN AGENT, DETECTING AN AGENT, DETECTING AN AGENT, DETECTING AN AGENT A SAMPLE TO BE TESTED, KITS FOR THE DETECTION OF A CANCER UMANTIGEN, AN ANTIGEN OF AN INFECTIOUS DISEASE AGENT, A CELL RECEPTOR FOR AN INFECTIOUS DISEASE AGENT, A BINDER, AND AN ANTIGENOUS OF CHARACTERISTICS OF OR AN APARTMENT FOR THE DEVELOPMENT OF A CANCER CERTIFIED BY THE INCREASED PRESENCE OF A CANCER UMANTIGEN, AND FOR THE PRESENCE OF AN INFECTIOUS DISEASE AGENT, PROCESSES OF PREVENTING OR PREVENTING A CANCER OF AN AGAINST AGAIN INFECTIOUS DISEASE AGENT ANTIGEN, EDE A DISEASE CAUSED BY AN INFECTIOUS DISEASE AGENT CONNECTING TO A CELLULAR RECEIVER, PROCESS FOR MODULATING THE ACTIVITY OF A FIRST MEMBER OF A CONNECTION PAIR, PROCESS OF DEPRODUCING A MODIFIED IMMUNE GLOBAL BODY, UNAUTHORGANIZED, UNHAPPY, UNHAPPY, UNHAPPY, UNHAPPY, UNHAPPY. ". The invention provides modified immunoglobulin molecules, particularly antibodies, that immunospecifically bind a member of a binding pair whose immunoglobulins have a variable domain containing one or more complementary determination regions that contain the amino acid sequence of a binding site for that member of the binding pair, whose site is derived from the other member of the binding pair and is not naturally found in the complementary determination region. The invention further provides for the use of the modified immunoglobulin in therapy and diagnosis.