Histological studies on tibial bone of rats in the 1975 COSMOS-782 flight. Part 2: Microradiographic study of cortical bone

摘要

The hypothesis based on a shift in the normal balance of internal structural remodelling of bone might account for reduction of bone mineral during prolonged weighlessness in earth-orbit is discussed. Rat cortical bone made by microradiography, on samples of tibia from rats in the 1975 COSMOS-782 experiment (together with synchronous and vivarium controls) is studied. Microradiographs were examined to provide semi-quantitative measurements of bone porosity and of mineral densities ranging from minimal to maximal in four proportionate ranges. Results suggested that ranges of mineral densities in these 3 month-old vivarium control rats were in accord with findings of other on human juveniles.