Receptor Monoclonal Antibodies that Inhibit Tumor Angiogenesis

摘要

The purpose of this project is to generate monoclonal antibodies to receptor molecules for the angiogenic growth factor VEGF. These antibodies will be tested for their potential as inhibitors of VEGF-stimulated angiogenesis, which is thought to play an important role in the development of breast cancer. A number of hybridomas have been screened for neutralizing activity, but no confirmed positives have yet been identified. Modifications to immunization and screening protocols are being made. Research demonstrating the direct binding of the intracellular signaling enzyme PI 3- kinase to the Flt-1 receptor is in press.