methods of inhibiting cathepsin s chemotherapy-induced up-regulation, cathepsin s expression on the surface of tumor cells and angiogenesis in a cell group, tissue or organ, of treating neoplastic disease and a condition associated with cathepsin s activity in a patient, inducing antibody-dependent cell-mediated cytotoxic reaction against a tumor cell, killing tumor cells, identifying tumor cells in a cell population, and evaluating an individual's tumor cell response in vitro the presence of a chemotherapeutic agent, uses of a cathepsin inhibitor if a chemotherapeutic agent of cathepsin s, an anti-cathepsin s antibody or a fragment thereof and an antibody molecule, pharmaceutical composition, pharmaceutical kit and antibody molecule or a nucleic acid encoding said antibody molecule

摘要

METHODS OF INHIBITING UPCOMING REGULATION INDUCED BY CATHYTESIN S CHEMOTHERAPY, EXHIBITION OF CATHATSIN ON THE SURFACE OF TUMOR CELLS AND ANGIOGENESIS IN A GROUP OF CELLS, A FABRIC OR AN ORGAN IN ACTIVITIES OF A COTTAGE ACTIVITY A PATIENT, INDUCING CYTOTOTIC REACTION MEASURED BY AN ANTIBODY DEPENDENT CELL AGAINST A TUMOR CELL, KILLING TUMOR CELLS, IDENTIFYING TUMOR CELLS IN A POPULATION OF CELLS AND EVALUATING A TOMOR CELL IN VARIOUS RESULTS PRESENCE OF A CHEMOTHERAPEUTIC AGENT, USES OF A CATHYTESIN INHIBITOR IF A CHEMOTHERAPEUTIC AGENT, OF CATHATSIN S, AN ANTI-CATHATPSIS AN ANTIBODY, A PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL AND PHARMACEUTICAL COMPOSITION A NUCLEIC ACID ENCODING THIS ANTIBODY MOLECULE The invention relates to a method of inhibiting regulatory regulation and induced by cathepsin S chemotherapy on the surface of tumor cells, the method comprising administering a cathepsin S inhibitor to said cells. Therapy is also envisaged which comprises an anti-cathepsin S antibody, in particular an anti-cathepsin S antibody which does not inhibit the proteolytic effect of cathepsin S but nevertheless inhibits angiogenesis and a combined treatment comprising a cathepsin S inhibitor and an agent therapeutic.