Liposomal Delivery Vehicles of Paclitaxel.

摘要

Paclitaxel stabilizes microtubules while inhibits mitotic spindle formation. It has been found to be effective in treating several solid cancers. The aim of this study was to incorporate paclitaxel in conventional and PEGylated liposomes, and to evaluate the antiproliferative effects of different formulations on MCF-7 and ZR75-1 cell lines. MTT assay was used to determine the growth inhibition of the cell line by paclitaxel. A significant dose-dependent inhibition of proliferation was found after the cells were exposed to certain liposomal paclitaxel preparations, suggesting the possible use of liposomes as effective paclitaxel delivery devices.