Drug and Vaccine Evaluation in the Human-Aotus Plasmodium Falciparum Model

摘要

This report presents data: On the evaluation of antimalarial drugs. Experimental drugs GJ-287 (WR282650; BP20546) and GJ-OZ (WR282651; BP20537) were non toxic when given to Aotus orally at 20 mg/kg for three consecutive days and only transient changes on blood leukograms and liver enzyme ALT were detected. These drugs were not effective alone or in combination with Chloroquine when Aotus monkeys infected with Plasmodium falciparum FVO strain were treated for three consecutive days. Significant differences on Lymphocytes and Granulocytes counts were found between male and female Aotus when hematological and renal chemistry values of feral laboratory adapted Aotus monkeys were determined. Artelinic Acid/Lysine Salt (WR255663 BP; 23565) intravenously for three consecutive days at 2 and 8 mg/kg respectively suppressed or cleared P. falciparum FVO parasitemia in Aotus monkeys. Artesunic acid administered intravenously for three consecutive days at 35 mg/kg cleared and cured parasitemias of P. falciparum FVO in infected Aotus monkeys.