Prostate Cancer in Nigerians, Jamaicans and U.S. Blacks

摘要

The purpose of this research was to develop the infrastructure for comparative studies of prostate cancer among blacks who reside in contrasting environmental settings: West Africa, the Caribbean, and the United States. This effort addresses six areas: case recruitment, case characterization, tissue collection and storage, integrated database development, targeted laboratory expertise, and pilot research. A one-year no-cost extension was granted to submit abstracts, manuscripts, and research proposals. Key Research Accomplishments: (1) established a research infrastructure to support unified measurement of exposure and prostate cancer disease in Chicago, Illinois, and Kingston, Jamaica; (2) completed molecular studies in over 40% of subjects enrolled; (3) created a computerized database linking demographic, clinical, and pathological characteristics of each case to archived tissue specimens and results of nutritional and genetic measurements; (4) completed statistical comparisons of the demographic, clinical, and pathological characteristics of cases from Chicago, Kingston, and West Africa; (5) completed statistical comparisons of the levels of antioxidants and fatty acids in serum and prostate tissue in cases diagnosed in Chicago and Jamaica; (6) performed association studies between variants of genes involved in androgen metabolism and prostate cancer stage within and across cases from Chicago, Jamaica, and West Africa; and (5) published two manuscripts and six abstracts.