Regulation of AR and (Beta)-Catenin Signaling by Pin 1 in Prostate Cancer

摘要

This mid-term report is a summary of the work accomplished during the past research year. The majority of this work was included in the attached Manuscript. Additional data were also included. Together our data support a positive role of Pin1 in PCa progression. We demonstrated that Pin1 can enhance beta-catenin nuclear localization, TCF/beta-catenin dependent promoter activity, and c-Myc and Cyclin D1 expression, while disrupt AR-mediated suppression of TCF/beta-catenin signaling. We also determined that Pin1 can reduce AR transcriptional activity and PSA expression, although the importance and the molecular basis for this Pin1 action are still not clear.